Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | of glia and nonmyelinating Schwann cells | Homo sapiens | 9986 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-L-aspartyl-L-glutamate + H2O | Homo sapiens | - |
L-glutamate + N-acetyl-L-aspartate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
cerebrospinal fluid | ventricular, lumbar, and subarachnoid | Homo sapiens | - |
glial cell | - |
Homo sapiens | - |
nonmyelinating Schwann cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-L-aspartyl-L-glutamate + H2O | - |
Homo sapiens | L-glutamate + N-acetyl-L-aspartate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCP II | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at, recombinant enzyme | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.7 | - |
assay at, recombinant enzyme | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of the GCP II-catalyzed reaction is beneficial for the treatment of degenerative diseases associated with excess glutamate. Inhibition of GCP II is neuroprotective in a variety of cell and animal models of disease involving excess glutamate. N-acetyl-aspartyl-glutamate can acts as a marker of glutamate carboxypeptidase II inhibition | Homo sapiens |