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Literature summary for 3.4.17.21 extracted from

  • Guilarte, T.R.; Hammoud, D.A.; McGlothan, J.L.; Caffo, B.S.; Foss, C.A.; Kozikowski, A.P.; Pomper, M.G.
    Dysregulation of glutamate carboxypeptidase II in psychiatric disease (2008), Schizophr. Res., 99, 324-332.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine glutamate carboxypeptidase II may represent a viable therapeutic target for intervention on psychiatric disease Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(S)-2-(3-((S)-1-carboxy-2-(4-hydroxy-3-iodophenyl)ethyl)ureido)pentanedioic acid DCIT Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-L-aspartyl-L-glutamate + H2O Homo sapiens
-
N-acetyl-L-aspartate + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
entorhinal cortex
-
Homo sapiens
-
hippocampus hippocampus-stratum lucidum Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
medial temporal lobe
-
Homo sapiens
-
prefrontal cortex
-
Homo sapiens
-
prostate
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
spinal cord
-
Homo sapiens
-
spleen
-
Homo sapiens
-
trachea
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-L-aspartyl-L-glutamate + H2O
-
Homo sapiens N-acetyl-L-aspartate + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
GCPII
-
Homo sapiens
glutamate carboxypeptidase II
-
Homo sapiens
Prostate-specific membrane antigen
-
Homo sapiens
PSMA
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000015
-
(S)-2-(3-((S)-1-carboxy-2-(4-hydroxy-3-iodophenyl)ethyl)ureido)pentanedioic acid
-
Homo sapiens