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Literature summary for 3.4.17.21 extracted from

  • Kozela, E.; Wrobel, M.; Kos, T.; Wojcikowski, J.; Daniel, W.A.; Wozniak, K.M.; Slusher, B.S.; Popik, P.
    2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice (2005), Psychopharmacology, 183, 275-284.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-(3-mercaptopropyl)-pentanedioic acid 2-MPPA, prevents morphine tolerance without affecting the acute morphine antinociception in vivo Mus musculus
2-(phosphonomethyl)-pentanedioic acid 2-PMPA Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Mus musculus the enzyme is responsible for glutamate supply, enzyme inhibition decreases the glutamate and increases the N-acetyl-alpha-L-aspartyl-L-glutamate concentration in the brain, which can be a method to treat opioid tolerance and diminish effects of morphine withdrawal, overview N-acetyl-alpha-L-aspartate + L-glutamate
-
?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Mus musculus C57/Bl the enzyme is responsible for glutamate supply, enzyme inhibition decreases the glutamate and increases the N-acetyl-alpha-L-aspartyl-L-glutamate concentration in the brain, which can be a method to treat opioid tolerance and diminish effects of morphine withdrawal, overview N-acetyl-alpha-L-aspartate + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57/Bl mice
-
Mus musculus C57/Bl
-
C57/Bl mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O the enzyme is responsible for glutamate supply, enzyme inhibition decreases the glutamate and increases the N-acetyl-alpha-L-aspartyl-L-glutamate concentration in the brain, which can be a method to treat opioid tolerance and diminish effects of morphine withdrawal, overview Mus musculus N-acetyl-alpha-L-aspartate + L-glutamate
-
?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O i.e. NAAG Mus musculus N-acetyl-alpha-L-aspartate + L-glutamate
-
?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O the enzyme is responsible for glutamate supply, enzyme inhibition decreases the glutamate and increases the N-acetyl-alpha-L-aspartyl-L-glutamate concentration in the brain, which can be a method to treat opioid tolerance and diminish effects of morphine withdrawal, overview Mus musculus C57/Bl N-acetyl-alpha-L-aspartate + L-glutamate
-
?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O i.e. NAAG Mus musculus C57/Bl N-acetyl-alpha-L-aspartate + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
GCP II
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000003
-
2-(phosphonomethyl)-pentanedioic acid
-
Mus musculus