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Literature summary for 3.4.17.21 extracted from

  • Zhong, C.; Zhao, X.; Sarva, J.; Kozikowski, A.; Neale, J.H.; Lyeth, B.G.
    NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats (2005), J. Neurotrauma, 22, 266-276.
    View publication on PubMed
Search for more literature for 3.4.17.21

Inhibitors

Inhibitors Comment Organism Structure
LY341495
-
 Rattus norvegicus
ZJ-43 i.e. (S)-2-[3-((S)-1-carboxy-3-methylbutyl)ureido]pentanedioic acid, the inhibitor enhances extracellular NAAG levels and reduces extracellular levels of amino acids neurotransmitter following traumatic brain injury in vivo Rattus norvegicus
ZJ43 i.e. (S)-2-[3-((S)-1-carboxy-3-methylbutyl)ureido]pentanedioic acid Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
synapse
-
 Rattus norvegicus 45202
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Rattus norvegicus enzyme inhibition reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion traumatic brain injury N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Rattus norvegicus NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Rattus norvegicus
-
brain
-
 Rattus norvegicus
-
hippocampus CA3 region, dorsal Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O enzyme inhibition reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion traumatic brain injury Rattus norvegicus N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats Rattus norvegicus N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O i.e. NAAG Rattus norvegicus N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
NAAG peptidase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 in vivo assay at Rattus norvegicus