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Literature summary for 3.4.17.21 extracted from

  • Ghadge, G.D.; Slusher, B.S.; Bodner, A.; Canto, M.D.; Wozniak, K.; Thomas, A.G.; Rojas, C.; Tsukamoto, T.; Majer, P.; Miller, R.J.; Monti, A.L.; Roos, R.P.
    Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models (2003), Proc. Natl. Acad. Sci. USA, 100, 9554-9559.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine GCPII inhibitors are attractive candidates for clinical treatment trials in amylotrophic lateral sclerosis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-(3-mercaptopropyl)pentanedioic acid orally bioavailable inhibitor Rattus norvegicus
2-(phosphonomethyl)pentanedioic acid requires long-term daily dosing Rattus norvegicus
additional information GCPII inhibitors are attractive candidates for clinical treatment trials in amylotrophic lateral sclerosis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-Asp-Glu + H2O Rattus norvegicus
-
 N-acetyl-Asp + Glu
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-Asp-Glu + H2O
-
 Rattus norvegicus N-acetyl-Asp + Glu
-
 ?

Synonyms

Synonyms Comment Organism
GCPII
-
 Rattus norvegicus