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Literature summary for 3.4.17.21 extracted from

  • Majer, P.; Jackson, P.F.; Delahanty, G.; Grella, B.S.; Ko, Y.S.; Li, W.; Liu, Q.; Maclin, K.M.; Polakova, J.; Shaffer, K.A.; Stoermer, D.; Vitharana, D.; Wang, E.Y.; Zakrzewski, A.; Rojas, C.; Slusher, B.S.; Wozniak, K.M.; Burak, E.; Limsakun, T.; Tsukamoto, T.
    Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor (2003), J. Med. Chem., 46, 1989-1996.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2-(3-mercaptopropyl)pentanedioic acid IC50: 90 nM. Orally bioavailable in rats Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-Asp-Glu + H2O
-
 Rattus norvegicus N-acetyl-Asp + Glu
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00009
-
 IC50: 90 nM. Orally bioavailable in rats Rattus norvegicus 2-(3-mercaptopropyl)pentanedioic acid