Cloned (Comment) | Organism |
---|---|
gene CPB2, gene mapping, genetic organization, DNA and amino acid sequence determination and analysis, regulation of enzyme expression involves the glucocorticoid receptor and the CCAAT/enhancer binding protein sites, polymorphisms at positions 325, 147, and 505 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A505G | naturally occurring polymorphism | Homo sapiens |
T147A | naturally occurring polymorphism | Homo sapiens |
T325I | naturally occurring polymorphism | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(6-aminopyridin-3-yl)-2-(1H-imidazol-4-yl)propanoic acid | IC50: 0.000001 mM | Homo sapiens | |
3-(6-aminopyridin-3-yl)-2-(sulfanylmethyl)propanoic acid | - |
Homo sapiens | |
5-amino-2-[(1-propyl-1H-imidazol-4-yl)methyl]pentanoic acid | - |
Homo sapiens | |
EF6265 | i.e. (S)-7-amino-2-[([(R)-2-methyl-1-(3-phenylpropanoylamino)propyl]hydroxyphosphinoyl)methyl]heptanoic acid, IC50: 0.000001 mM | Homo sapiens | |
epsilon-aminocaproic acid | - |
Homo sapiens | |
GEMSA | i.e. guanidinoethyl-thiopropanoic acid | Homo sapiens | |
LCI | leech carboxypeptidase inhibitor | Homo sapiens | |
MERGETPA | D,L-2-mercaptomethyl-3-guanidinoethyl-thipropanoic acid | Homo sapiens | |
PCI-2KR | i.e. peptide CKPAKNRC | Homo sapiens | |
PTCI | potato carboxypeptidase inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a metallocarboxypeptidase with a penta-coordinated zinc ion | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
anaphylatoxin C3a + H2O | Homo sapiens | inactivation of the inflammatory mediator | ? | - |
? | |
anaphylatoxin C5a + H2O | Homo sapiens | inactivation of the inflammatory mediator | ? | - |
? | |
additional information | Homo sapiens | the enzyme inhibits fibrinolysis and has a distinct role in haemostasis and a possible risk factor for thrombotic disease involving the polymorphism at position 325, overview, the plasminogen activation system plays a role in enzyme regulation | ? | - |
? | |
osteopontin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | different glycosylation patterns dependent on the enzyme source | Homo sapiens |
proteolytic modification | activation pathways overview, cleavage of the activation peptide from proCPU, in vitro catalyzed through thrombin, meizothrombin, plasmin, trypsin, or neutrophil elastase, only the thrombin cleaved enzyme is active, in vivo by the thrombin/thrombomodulin complex in a Ca2+-dependent manner, kinetics, overview, the plasminogen activation system, overview | Homo sapiens |
Purification (Comment) | Organism |
---|---|
from plasma by a plasminogen affinity based method | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
release of C-terminal Arg and Lys from a polypeptide | catalytic mechanism and substrate specificity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
blood platelet | - |
Homo sapiens | - |
epithelium | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | alveolar epithelium and macrophages, broncheal epithelium | Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
additional information | analysis of expression and distribution, overview, no expression in brain, kidney, placenta, and skeletal muscle | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme plasma concentration of healthy male persons, correlation of enzyme plasma concentration to cardiovascular diseases, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
anaphylatoxin C3a + H2O | - |
Homo sapiens | ? | - |
? | |
anaphylatoxin C3a + H2O | inactivation of the inflammatory mediator | Homo sapiens | ? | - |
? | |
anaphylatoxin C5a + H2O | - |
Homo sapiens | ? | - |
? | |
anaphylatoxin C5a + H2O | inactivation of the inflammatory mediator | Homo sapiens | ? | - |
? | |
additional information | the enzyme inhibits fibrinolysis and has a distinct role in haemostasis and a possible risk factor for thrombotic disease involving the polymorphism at position 325, overview, the plasminogen activation system plays a role in enzyme regulation | Homo sapiens | ? | - |
? | |
osteopontin + H2O | - |
Homo sapiens | ? | - |
? | |
osteopontin + H2O | thrombin-cleaved substrate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxypeptidase U | - |
Homo sapiens |
CPU | - |
Homo sapiens |
proCPU | - |
Homo sapiens |
TAFIa | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
- |
- |
stable for several days | Homo sapiens |
37 | - |
body temperature, spontaneous decay, half-life 10 min | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000001 | - |
3-(6-aminopyridin-3-yl)-2-(sulfanylmethyl)propanoic acid | - |
Homo sapiens | |
0.000001 | - |
LCI | - |
Homo sapiens | |
0.00001 | - |
PCI-2KR | - |
Homo sapiens | |
0.0001 | - |
5-amino-2-[(1-propyl-1H-imidazol-4-yl)methyl]pentanoic acid | - |
Homo sapiens | |
0.0001 | 0.001 | MERGETPA | - |
Homo sapiens | |
0.001 | 0.1 | GEMSA | - |
Homo sapiens | |
110 | - |
epsilon-aminocaproic acid | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
i.e. (S)-7-amino-2-[([(R)-2-methyl-1-(3-phenylpropanoylamino)propyl]hydroxyphosphinoyl)methyl]heptanoic acid, IC50: 0.000001 mM | Homo sapiens | EF6265 | |
0.000001 | - |
IC50: 0.000001 mM | Homo sapiens | 3-(6-aminopyridin-3-yl)-2-(1H-imidazol-4-yl)propanoic acid |