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Literature summary for 3.4.17.20 extracted from

  • Matthews, K.W.; Mueller-Ortiz, S.L.; Wetsel, R.A.
    Carboxypeptidase N: a pleiotropic regulator of inflammation (2004), Mol. Immunol., 40, 785-793.
    View publication on PubMed
Search for more literature for 3.4.17.20

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular plasma Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ the enzyme is a metallopeptidase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme might be the primary in vivo regulator of complement component C5a-mediated inflammation in the circulation, the enzyme cleaves terminal lysine from the surface of fibrin clots preventing the binding and activation of plasminogen and inhibiting whole blood clot lysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the enzyme is synthesized as zymogen, activation by the thrombin/thrombomodulin complex or by plasmin Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
release of C-terminal Arg and Lys from a polypeptide the enzyme prefers C-terminal arginine over lysine Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3a octapeptide + H2O removal of terminal arginine, low activity Homo sapiens ?
-
 ?
complement component C5a octapeptide + H2O removal of terminal arginine Homo sapiens ?
-
 ?
additional information the enzyme might be the primary in vivo regulator of complement component C5a-mediated inflammation in the circulation, the enzyme cleaves terminal lysine from the surface of fibrin clots preventing the binding and activation of plasminogen and inhibiting whole blood clot lysis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CPR
-
 Homo sapiens
CPU
-
 Homo sapiens
TAFI
-
 Homo sapiens
thrombin activatable fibrinolysis inhibitor
-
 Homo sapiens