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Literature summary for 3.4.17.20 extracted from

  • Mao, S.S.; Colussi, D.; Bailey, C.M.; Bosserman, M.; Burlein, C.; Gardell, S.J.; Carroll, S.S.
    Electrochemiluminescence assay for basic carboxypeptidases: inhibition of basic carboxypeptidases and activation of thrombin-activatable fibrinolysis inhibitor (2003), Anal. Biochem., 319, 159-170.
    View publication on PubMed
Search for more literature for 3.4.17.20

Inhibitors

Inhibitors Comment Organism Structure
2-Guanidinoethylmercaptosuccinic acid
-
 Homo sapiens
DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid
-
 Homo sapiens
epsilon-aminocaproic acid
-
 Homo sapiens
potato carboxypeptidase inhibitor
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
 biotinyl-(epsilon-aminocaproic acid)-(epsilon-aminocaproic acid)-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Arg-OH room temperature Homo sapiens

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Chlorocebus aethiops
-
-
-
Homo sapiens
-
-
-
Macaca mulatta
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
development of a method to isolate in situ activated TAFIa from human serum in presence of epsilon-aminocaproic acid Homo sapiens
development of a method to isolate in situ activated TAFIa from serum in presence of epsilon-aminocaproic acid Rattus norvegicus
development of a method to isolate in situ activated TAFIa from serum in presence of epsilon-aminocaproic acid Canis lupus familiaris
development of a method to isolate in situ activated TAFIa from serum in presence of epsilon-aminocaproic acid Macaca mulatta
development of a method to isolate in situ activated TAFIa from serum in presence of epsilon-aminocaproic acid Chlorocebus aethiops

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
 Homo sapiens
-
blood serum
-
 Rattus norvegicus
-
blood serum
-
 Canis lupus familiaris
-
blood serum
-
 Macaca mulatta
-
blood serum
-
 Chlorocebus aethiops
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 electroluminescence assay. The high sensitivity of the assay allows the determination of the activatable levels of TAFI in human and other animal plasma in presence of epsilon-aminocaproic acid, an active-site inhibitor that stabilizes TAFIa Homo sapiens
additional information
-
 electroluminescence assay. The high sensitivity of the assay allows the determination of the activatable levels of TAFI in human and other animal plasma in presence of epsilon-aminocaproic acid, an active-site inhibitor that stabilizes TAFIa Rattus norvegicus
additional information
-
 electroluminescence assay. The high sensitivity of the assay allows the determination of the activatable levels of TAFI in human and other animal plasma in presence of epsilon-aminocaproic acid, an active-site inhibitor that stabilizes TAFIa Canis lupus familiaris
additional information
-
 electroluminescence assay. The high sensitivity of the assay allows the determination of the activatable levels of TAFI in human and other animal plasma in presence of epsilon-aminocaproic acid, an active-site inhibitor that stabilizes TAFIa Macaca mulatta
additional information
-
 electroluminescence assay. The high sensitivity of the assay allows the determination of the activatable levels of TAFI in human and other animal plasma in presence of epsilon-aminocaproic acid, an active-site inhibitor that stabilizes TAFIa Chlorocebus aethiops

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biotinyl-(epsilon-aminocaproic acid)-(epsilon-aminocaproic acid)-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Arg-OH + H2O
-
 Homo sapiens biotinyl-(epsilon-aminocaproic acid)-(epsilon-aminocaproic acid)-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH + Arg
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3
-
 biotinyl-(epsilon-aminocaproic acid)-(epsilon-aminocaproic acid)-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Arg-OH room temperature Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information the Ki-value for protamine is above 50 mM Homo sapiens
0.0000021
-
 potato carboxypeptidase inhibitor
-
 Homo sapiens
0.0002
-
 DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid
-
 Homo sapiens
0.0044
-
 2-Guanidinoethylmercaptosuccinic acid
-
 Homo sapiens
1
-
 epsilon-aminocaproic acid
-
 Homo sapiens