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Literature summary for 3.4.17.2 extracted from

  • Fernandez, D.; Aviles, F.X.; Vendrell, J.
    A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases (2009), Eur. J. Med. Chem., 44, 3266-3271.
    View publication on PubMed
Search for more literature for 3.4.17.2

Inhibitors

Inhibitors Comment Organism Structure
1-(4-chlorophenyl)-2-(5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-ylthio)ethanone
-
 Helicoverpa zea
1-(4-chlorophenyl)-2-(5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-ylthio)ethanone
-
 Homo sapiens
2-(6,9-dimethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(4-fluorophenyl)ethanone
-
 Helicoverpa zea
4-(5-(2-chlorobenzylthio)-1,3,4-oxadiazol-2-yl)-N-(thiophen-2-ylmethyl)benzensulfonamide
-
 Helicoverpa zea
DL-benzylsuccinic acid
-
 Helicoverpa zea
DL-benzylsuccinic acid
-
 Homo sapiens
DL-guanidinoethylmercaptosuccinic acid
-
 Homo sapiens
isopropyl 2-(4-benzyl-5-(2-methoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate
-
 Helicoverpa zea
isopropyl 2-(4-benzyl-5-(2-methoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate
-
 Homo sapiens
methyl 2-(4-benzyl-5-(2-hydroxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate
-
 Helicoverpa zea
methyl 2-(4-benzyl-5-(2-hydroxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate
-
 Homo sapiens
N-(3-chlorophenyl)-4-((5-((3-methoxybenzyl)thio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine
-
 Helicoverpa zea
N-(3-chlorophenyl)-4-((5-((3-methoxybenzyl)thio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine
-
 Homo sapiens
N-benzyl-N-(4-phenylthiazol-2-yl)cyclopropanecarboxamide
-
 Helicoverpa zea
N-benzyl-N-(4-phenylthiazol-2-yl)cyclopropanecarboxamide
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
 N-(4-methoxyphenylazoformyl)-Arg
-
 Homo sapiens
0.06
-
 N-(4-methoxyphenylazoformyl)-Arg
-
 Helicoverpa zea

Organism

Organism UniProt Comment Textmining
Helicoverpa zea
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(4-methoxyphenylazoformyl)-Arg + H2O
-
 Homo sapiens ?
-
 ?
N-(4-methoxyphenylazoformyl)-Arg + H2O
-
 Helicoverpa zea ?
-
 ?

Synonyms

Synonyms Comment Organism
carboxypeptidase B
-
 Homo sapiens
carboxypeptidase B
-
 Helicoverpa zea
CPB
-
 Homo sapiens
HzCPB
-
 Helicoverpa zea

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
additional information
-
 assay at room temperature Homo sapiens
additional information
-
 assay at room temperature Helicoverpa zea

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens
7.5
-
 assay at Helicoverpa zea

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
 1-(4-chlorophenyl)-2-(5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-ylthio)ethanone pH 7.5 Helicoverpa zea
0.0011
-
 DL-guanidinoethylmercaptosuccinic acid pH 7.5 Homo sapiens
0.0012
-
 N-benzyl-N-(4-phenylthiazol-2-yl)cyclopropanecarboxamide pH 7.5 Helicoverpa zea
0.0012
-
 N-(3-chlorophenyl)-4-((5-((3-methoxybenzyl)thio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine pH 7.5 Homo sapiens
0.0014
-
 4-(5-(2-chlorobenzylthio)-1,3,4-oxadiazol-2-yl)-N-(thiophen-2-ylmethyl)benzensulfonamide pH 7.5 Helicoverpa zea
0.0036
-
 N-(3-chlorophenyl)-4-((5-((3-methoxybenzyl)thio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine pH 7.5 Helicoverpa zea
0.0045
-
 N-benzyl-N-(4-phenylthiazol-2-yl)cyclopropanecarboxamide pH 7.5 Homo sapiens
0.0049
-
 methyl 2-(4-benzyl-5-(2-hydroxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate pH 7.5 Homo sapiens
0.0074
-
 isopropyl 2-(4-benzyl-5-(2-methoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate pH 7.5 Homo sapiens
0.0075
-
 1-(4-chlorophenyl)-2-(5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-ylthio)ethanone pH 7.5 Homo sapiens
0.009
-
 2-(6,9-dimethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(4-fluorophenyl)ethanone pH 7.5 Helicoverpa zea
0.01
-
 DL-benzylsuccinic acid pH 7.5 Homo sapiens
0.0119
-
 DL-benzylsuccinic acid pH 7.5 Helicoverpa zea
0.0361
-
 isopropyl 2-(4-benzyl-5-(2-methoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate pH 7.5 Helicoverpa zea
0.0416
-
 methyl 2-(4-benzyl-5-(2-hydroxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate pH 7.5 Helicoverpa zea