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Literature summary for 3.4.17.2 extracted from

  • Fernandez, D.; Torres, E.; Aviles, F.X.; Ortuno, R.M.; Vendrell, J.
    Cyclobutane-containing peptides: evaluation as novel metallocarboxypeptidase inhibitors and modelling of their mode of action (2009), Bioorg. Med. Chem., 17, 3824-3828.
    View publication on PubMed
Search for more literature for 3.4.17.2

Cloned(Commentary)

Cloned (Comment) Organism
recombinantly expressed Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
methyl (1R,2S)-2-([[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)cyclobutanecarboxylate
-
 Homo sapiens
methyl (1S,2R)-2-([[(1S,2R)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)cyclobutanecarboxylate
-
 Homo sapiens
methyl 5-([[(1S,2R)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)pentanoate
-
 Homo sapiens
methyl N-[[(1R,2S)-2-([N-[(benzyloxy)carbonyl]-beta-alanyl]amino)cyclobutyl]carbonyl]-beta-alaninate
-
 Homo sapiens
methyl N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]-beta-alaninate
-
 Homo sapiens
methyl N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]glycinate
-
 Homo sapiens
N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]-beta-alaninate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(4-methoxyphenylazoformyl)-Arg + H2O
-
 Homo sapiens ?
-
 ?
N-(4-methoxyphenylazoformyl)-Phe + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
carboxypeptidase B
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.043
-
 N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]-beta-alaninate pH 7.5, 22°C Homo sapiens
0.07
-
 methyl (1S,2R)-2-([[(1S,2R)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)cyclobutanecarboxylate pH 7.5, 22°C Homo sapiens
0.165
-
 methyl N-[[(1R,2S)-2-([N-[(benzyloxy)carbonyl]-beta-alanyl]amino)cyclobutyl]carbonyl]-beta-alaninate pH 7.5, 22°C Homo sapiens
0.275
-
 methyl (1R,2S)-2-([[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)cyclobutanecarboxylate pH 7.5, 22°C Homo sapiens
0.4
-
 methyl N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]-beta-alaninate pH 7.5, 22°C Homo sapiens
0.41
-
 methyl 5-([[(1S,2R)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)pentanoate pH 7.5, 22°C Homo sapiens
0.5
-
 methyl N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]glycinate pH 7.5, 22°C Homo sapiens