BRENDA - Enzyme Database show
show all sequences of 3.4.17.17

Activation of tubulinyl-tyrosine carboxypeptidase by spermine, spermidine and putrescine

Barra, H.S.; Argarana, C.E.; Biochem. Biophys. Res. Commun. 108, 654-657 (1982)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
putrescine
maximal stimulation at 6 mM
Gallus gallus
spermidine
stimulates, maximal stimulation at 1 mM, inhibition above
Gallus gallus
spermine
maximal stimulation at 0.06 mM
Gallus gallus
Inhibitors
Inhibitors
Commentary
Organism
Structure
putrescine
inhibition above 6 mM
Gallus gallus
spermidine
inhibition above 1 mM
Gallus gallus
spermine
above 0.06 mM
Gallus gallus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
activates, maximal activation at 4-6 mM
Gallus gallus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Gallus gallus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Gallus gallus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
tyrosinated tubulin + H2O
-
647264
Gallus gallus
tubulin + Tyr
-
647264
Gallus gallus
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
putrescine
maximal stimulation at 6 mM
Gallus gallus
spermidine
stimulates, maximal stimulation at 1 mM, inhibition above
Gallus gallus
spermine
maximal stimulation at 0.06 mM
Gallus gallus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
putrescine
inhibition above 6 mM
Gallus gallus
spermidine
inhibition above 1 mM
Gallus gallus
spermine
above 0.06 mM
Gallus gallus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
activates, maximal activation at 4-6 mM
Gallus gallus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Gallus gallus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
tyrosinated tubulin + H2O
-
647264
Gallus gallus
tubulin + Tyr
-
647264
Gallus gallus
?
Other publictions for EC 3.4.17.17
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
686295
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200-210
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1
1
1
-
1
-
1
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1
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1
-
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3
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1
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1
1
1
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1
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1
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3
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1
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-
-
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-
-
-
-
672915
Fonrose
Parthenolide inhibits tubulin ...
Homo sapiens
Cancer Res.
67
3371-3378
2007
-
1
-
-
-
-
4
-
-
-
-
-
-
2
-
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1
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1
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4
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1
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1
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686639
Rodriguez de la Vega
Nna1-like proteins are active ...
Caenorhabditis elegans
FASEB J.
21
851-865
2007
2
1
1
-
-
-
2
-
1
1
-
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4
-
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1
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1
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2
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1
1
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1
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-
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-
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-
-
-
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687835
Vassal
Miniaturization and validation ...
Homo sapiens
J. Biomol. Screen.
11
377-389
2006
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
-
1
-
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1
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1
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-
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-
-
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-
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-
-
-
-
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647266
Contin
Inhibitors of protein phosphat ...
Cricetulus griseus, Mus musculus, Rattus norvegicus
Eur. J. Biochem.
270
4921-4929
2003
-
-
1
-
-
-
-
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1
-
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1
-
3
-
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-
2
-
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4
-
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-
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-
-
-
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1
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-
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1
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-
1
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2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
647265
Lopez
Effect of polyanions and polyc ...
Rattus norvegicus
Biochim. Biophys. Acta
1039
209-217
1990
-
-
-
-
-
1
4
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
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-
-
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-
-
-
-
-
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-
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1
-
4
-
-
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-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647262
Weizetfel
The integrity of tubulin molec ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
159
770-776
1989
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
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1
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1
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1
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-
647263
Modesti
The interaction of myelin basi ...
Bos taurus
Biochem. Biophys. Res. Commun.
136
482-489
1986
-
-
-
-
-
-
1
-
-
-
-
-
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1
-
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-
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1
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1
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1
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1
-
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1
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647258
Arce
Association of tubulinyl-tyros ...
Rattus norvegicus
FEBS Lett.
157
75-78
1983
-
-
-
-
-
-
-
-
-
-
-
-
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1
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1
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1
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1
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1
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1
-
-
1
-
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-
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-
-
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-
-
-
-
-
-
-
647264
Barra
Activation of tubulinyl-tyrosi ...
Gallus gallus
Biochem. Biophys. Res. Commun.
108
654-657
1982
3
-
-
-
-
-
3
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
1
-
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-
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3
-
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3
-
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1
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647260
Argarana
Inhibition of tubulinyl-tyrosi ...
Gallus gallus
J. Biol. Chem.
256
827-830
1981
-
-
-
-
-
-
2
-
-
-
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-
-
1
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1
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1
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2
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1
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1
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-
647261
Kumar
Preferential action of a brain ...
Bos taurus
J. Biol. Chem.
256
7678-7686
1981
-
-
-
-
-
-
1
-
-
-
-
-
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1
-
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1
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647259
Argarana
Tubulinyl-tyrosine carboxypept ...
Gallus gallus
J. Neurochem.
34
114-118
1980
-
-
-
-
-
1
10
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
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-
-
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-
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1
-
10
-
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1
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1
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1
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-
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