Protein Variants | Comment | Organism |
---|---|---|
additional information | the enzyme mutant K23 of Brucella abortus fails to replicate in mouse macrophages and HeLa cells, and shows less virulence than the wild type in mice, Under nitric oxide (NO) stress, the growth of the DAP mutant in vitro decreases, and it also has less capability to reduce NO than the wild type, intracellular replication of the DAP mutant is partially restored by pretreatment of macrophages with the NO synthase inhibitor 1-phenyl-imidazole and the level of expression of the NO reductase gene norB in the DAP mutant is lower than that in the wild type | Brucella abortus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Brucella abortus | DAP contributes to resistance against NO required for the intracellular growth of the bacterium | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Brucella abortus | - |
strain 544, ATCC 23448, a smooth virulent biovar 1 strain, gene dacF | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | intracellular replication of Brucella abortus within murine macrophages and HeLa cells | Brucella abortus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | DAP contributes to resistance against NO required for the intracellular growth of the bacterium | Brucella abortus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D-alanyl-D-alanine carboxypeptidase | - |
Brucella abortus |
DAP | - |
Brucella abortus |