BRENDA - Enzyme Database
show all sequences of 3.4.17.12

Epoetin delta reduces oxidative stress in primary human renal tubular cells

De Beuf, A.; Hou, X.H.; DHaese, P.C.; Verhulst, A.; J. Biomed. Biotechnol. 2010, 395785 (2010)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
additional information
primary human renal tubular epithelial cell
Homo sapiens
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
additional information
primary human renal tubular epithelial cell
Homo sapiens
-
Expression
Organism
Commentary
Expression
Homo sapiens
oxidative stress reduction by epoetin delta goes along with the upregulation of renoprotective genes. The expression of carboxypeptidase M is significantly upregulated upon erythropoietin administration in and only in those cell cultures in which an erythropoietin-induced cytoprotective effect is seen. In cultures in which epoetin delta does not show protective effects, no upregulation of carboxypeptidase M is observed
up
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
oxidative stress reduction by epoetin delta goes along with the upregulation of renoprotective genes. The expression of carboxypeptidase M is significantly upregulated upon erythropoietin administration in and only in those cell cultures in which an erythropoietin-induced cytoprotective effect is seen. In cultures in which epoetin delta does not show protective effects, no upregulation of carboxypeptidase M is observed
up
Other publictions for EC 3.4.17.12
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732121
Zhang
Carboxypeptidase M is a positi ...
Homo sapiens
J. Biol. Chem.
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33226-33240
2013
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732261
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Mapping of carboxypeptidase m ...
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61
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2013
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709174
De Beuf
Epoetin delta reduces oxidativ ...
Homo sapiens
J. Biomed. Biotechnol.
2010
395785
2010
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Guimaraes
Multiple RNAs from the mouse c ...
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697395
Deiteren
Carboxypeptidase M: Multiple a ...
Homo sapiens
Clin. Chim. Acta
399
24-39
2009
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8
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709860
Erickson-Johnson
Carboxypeptidase M: a biomarke ...
Homo sapiens
Mod. Pathol.
22
1541-1547
2009
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683685
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Carboxypeptidase M and kinin B ...
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2008
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684066
Marquez-Curtis
Carboxypeptidase M expressed b ...
Homo sapiens
Stem Cells
26
1211-1220
2008
1
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697627
Abdelmagid
Prolactin and estrogen up-regu ...
Homo sapiens
Endocrinology
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2008
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683186
Deiteren
The role of the S1 binding sit ...
Homo sapiens
Biochim. Biophys. Acta
1774
267-277
2007
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1
40
1
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29
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40
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40
1
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683544
Schremmer-Danninger
Kinin receptors in stimulated ...
Homo sapiens
Int. Immunopharmacol.
7
103-112
2007
1
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683976
Fujiwara
Membrane-bound peptidases regu ...
Homo sapiens
Placenta
28 Suppl A
S70-S75
2007
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1
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684055
Fujiwara
Monoclonal antibody 7F9 recogn ...
Rattus norvegicus
Respirology
12
54-62
2007
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668124
Craveiro
High expression of human carbo ...
Homo sapiens
Braz. J. Med. Biol. Res.
39
211-217
2006
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1
1
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2
1
1
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4
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1
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10
1
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10
1
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683099
Ahmad
Degradation of bradykinin, a c ...
Rattus norvegicus
Arch. Pharm. Res.
29
241-248
2006
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683200
Skidgel
Kinin- and angiotensin-convert ...
Bos taurus, Homo sapiens
Biol. Chem.
387
159-165
2006
2
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684105
van Hemert
Immunological and gene express ...
Gallus gallus
Vet. Res.
38
51-63
2006
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668817
Skidgel
-
Carboxypeptidase M ...
Canis lupus familiaris, Homo sapiens
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. ) Academic Press
2
851-854
2004
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3
3
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11
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669830
Reverter
Crystal structure of human car ...
Homo sapiens
J. Mol. Biol.
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257-269
2004
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670291
Matthews
Carboxypeptidase N: a pleiotro ...
Homo sapiens
Mol. Immunol.
40
785-793
2004
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647253
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1995
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Deddish
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Canis lupus familiaris
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15083-15089
1990
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647252
Skidgel
Human carboxypeptidase M. Puri ...
Homo sapiens
J. Biol. Chem.
264
2236-2241
1989
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