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Literature summary for 3.4.17.12 extracted from

  • Matthews, K.W.; Mueller-Ortiz, S.L.; Wetsel, R.A.
    Carboxypeptidase N: a pleiotropic regulator of inflammation (2004), Mol. Immunol., 40, 785-793.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
plasma membrane anchored via glycosylphosphatidylinositol Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ the enzyme is a metallopeptidase, binding to His66 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme might be involved in regulating the biological effects of complement anaphylatoxins at sites of tissue injury ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information the enzyme is not expressed as zymogen Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
cleavage of C-terminal arginine or lysine residues from polypeptides substrate binding via residue Tyr266 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
Homo sapiens
-
kidney
-
Homo sapiens
-
lung
-
Homo sapiens
-
macrophage
-
Homo sapiens
-
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme might be involved in regulating the biological effects of complement anaphylatoxins at sites of tissue injury Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
CPM
-
Homo sapiens
More the enzyme belongs to the CPN subgroup of mammalian carboxypeptidases Homo sapiens