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Literature summary for 3.4.17.11 extracted from

  • Mancini, L.; Davies, L.; Friedlos, F.; Falck-Miniotis, M.; Dzik-Jurasz, A.S.; Springer, C.J.; Leach, M.O.; Payne, G.S.
    A novel technique to monitor carboxypeptidase G2 expression in suicide gene therapy using (19)F magnetic resonance spectroscopy (2009), NMR Biomed., 22, 561-566.
    View publication on PubMed
Search for more literature for 3.4.17.11

Application

Application Comment Organism
medicine CPG2 possesses several properties that make it suitable for suicide gene therapy Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00171
-
 [4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid
-
 Homo sapiens
0.0035
-
 [4-[bis(2-hydroxyethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human cancer cell lines are targeted by a vector carrying the CPG2 gene, CPG2 gene originates from different organism
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-361 cell target cell for gene therapy Homo sapiens
-
WiDr cell target cell for gene therapy Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid + H2O prodrug activated by CPG2 Homo sapiens ?
-
 ?
[4-[bis(2-hydroxyethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid + H2O prodrug activated by CPG2 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
carboxypeptidase G2
-
 Homo sapiens
CPG2
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
732
-
 [4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid
-
 Homo sapiens
747
-
 [4-[bis(2-hydroxyethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid
-
 Homo sapiens