Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.17.10 extracted from

  • Davidson, H.W.; Hutton, J.C.
    The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing (1987), Biochem. J., 245, 575-582.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Rattus norvegicus
CuCl2
-
Rattus norvegicus
EDTA
-
Rattus norvegicus
FeSO4
-
Rattus norvegicus
Guanidinoethylmercaptosuccinic acid
-
Rattus norvegicus
HgCl2
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0175
-
dansyl-Phe-Leu-Arg
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory granule
-
Rattus norvegicus 30141
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ activates Rattus norvegicus
NiCl2 stimulates Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
non-denaturing PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus biosynthesis of insulin in pancreatic beta-cells ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification glycoprotein Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
insulinoma cell
-
Rattus norvegicus
-
pancreas
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
15.5
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Dansyl-Phe-Ala-Arg + H2O
-
Rattus norvegicus Dansyl-Phe-Ala + Arg
-
?
Dansyl-Phe-Leu-Arg + H2O
-
Rattus norvegicus Dansyl-Phe-Leu + Arg
-
?
additional information biosynthesis of insulin in pancreatic beta-cells Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 55000, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 6
-
Rattus norvegicus
5.5
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
4 6.5 pH 4: about 20% of activity maximum, pH 6.5: about 15% of activity maximum Rattus norvegicus