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Literature summary for 3.4.17.10 extracted from
- Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors (2017), Int. J. Oncol., 51, 702-714 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q00493 | - |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | overexpression of the secreted form of CPE is accompanied by differential regulation of mRNAs connected to the motility-associated networks, among others adhesion kinase FAK, p21-activated kinase PAK, cell division cycle 42 (Cdc42), integrin, STAT3 as well as TGF-beta. Especially SLUG is downregulated in sCPE-overexpressing glioma cells, paralleled by reduced expression of matrix-metalloproteinases (MMP) and, in consequence, by decreased cell migration. Expression of SLUG is regulated by ERK since inhibition of ERK reverted sCPE-mediated SLUG downregulation and enhanced cell motility. In a mouse glioma model, overexpression of the sectreted form of CPE significantly prolonges survival | Mus musculus |
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Release 2023.1 (January 2023)
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