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Literature summary for 3.4.17.10 extracted from
- Neurotrophic, gene regulation, and cognitive functions of carboxypeptidase E-neurotrophic factor-alpha1 and its variants (2019), Front. Neurosci., 13, 243 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P16870 | - |
- |
| Mus musculus | Q00493 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CPE-NFalpha1 | - |
Mus musculus |
| CPE-NFalpha1 | - |
Homo sapiens |
| neurotrophic factor-alpha1 | - |
Mus musculus |
| neurotrophic factor-alpha1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme cleaves C-terminal basic amino acids from prohormone intermediates to produce mature peptide hormones and neuropeptides in the endocrine and central nervous systems. It also plays a critical role in prohormone sorting and secretory vesicle transportation. The enzyme exerts multiple non-enzymatic physiological roles in maintaining normal central nervous system function and in neurodevelopment. This includes potent neuroprotective and anti-depressant activities, as well as stem cell differentiation functions. In addition, N-terminal truncated variants of the enzyme regulate expression of important neurodevelopmental genes | Mus musculus |
| physiological function | the enzyme cleaves C-terminal basic amino acids from prohormone intermediates to produce mature peptide hormones and neuropeptides in the endocrine and central nervous systems. It also plays a critical role in prohormone sorting and secretory vesicle transportation. The enzyme exerts multiple non-enzymatic physiological roles in maintaining normal central nervous system function and in neurodevelopment. This includes potent neuroprotective and anti-depressant activities, as well as stem cell differentiation functions. In addition, N-terminal truncated variants of the enzyme regulate expression of important neurodevelopmental genes | Homo sapiens |
| physiological function | the enzyme plays a critical role in prohormone sorting and secretory vesicle transportation | Mus musculus |
| physiological function | the enzyme plays a critical role in prohormone sorting and secretory vesicle transportation | Homo sapiens |
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Release 2023.1 (January 2023)
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