Literature summary for 3.4.17.10 extracted from

Oiso, S.; Takeda, Y.; Futagawa, T.; Miura, T.; Kuchiiwa, S.; Nishida, K.; Ikeda, R.; Kariyazono, H.; Watanabe, K.; Yamada, K.
Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the CNS (2009), J. Neurochem., 109, 158-167.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
carboxypeptidase E	-	Homo sapiens
CPE	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	glutathione S-transferase pull-down and immunoprecipitation analyses indicate that contactin-associated protein 2 is associated with carboxypeptidase E in vitro and in vivo. Both contactin-associated protein 2 and carboxypeptidase E are expressed predominantly in the CNS. Immunohistochemical analysis reveals that both contactin-associated protein 2- and carboxypeptidase E-like immunoreactivities are found to co-localize in the apical dendrites and cell bodies of rat cortical neurons. In subcellular localization analysis, contactin-associated protein 2- and carboxypeptidase E-like immunoreactivities are co-migrated in the fractions of Golgi/ER. The membrane-bound form of carboxypeptidase E functions as a sorting receptor of prohormones in the trans-Golgi network. Carboxypeptidase E may be a key molecule to regulate contactin-associated protein 2 trafficking to the cell membrane	Homo sapiens

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Release 2023.1 (January 2023)