Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.17.1 extracted from

  • Deckert, P.M.; Bornmann, W.G.; Ritter, G.; Williams, C.; Franke, J.; Keilholz, U.; Thiel, E.; Old, L.J.; Bertino, J.R.; Welt, S.
    Specific tumour localisation of a huA33 antibody-carboxypeptidase A conjugate and activation of methotrexate-phenylalanine (2004), Int. J. Oncol., 24, 1289-1295.
    View publication on PubMed

Application

Application Comment Organism
medicine evaluation of an antibody-directed enzyme-prodrug therapy for anticancer treatment using the A33 antigen, the enzyme, and methotrexate-phenylalanine as prodrug, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methotrexate-phenylalanine + H2O Homo sapiens prodrug activation in SW122 cells methotrexate + phenylalanine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SW-1222 cell antigen A33-prositive colon carcinoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methotrexate-phenylalanine + H2O
-
Homo sapiens methotrexate + phenylalanine
-
?
methotrexate-phenylalanine + H2O prodrug activation in SW122 cells Homo sapiens methotrexate + phenylalanine
-
?

Synonyms

Synonyms Comment Organism
CPA
-
Homo sapiens