Application | Comment | Organism |
---|---|---|
medicine | evaluation of an antibody-directed enzyme-prodrug therapy for anticancer treatment using the A33 antigen, the enzyme, and methotrexate-phenylalanine as prodrug, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
methotrexate-phenylalanine + H2O | Homo sapiens | prodrug activation in SW122 cells | methotrexate + phenylalanine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SW-1222 cell | antigen A33-prositive colon carcinoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methotrexate-phenylalanine + H2O | - |
Homo sapiens | methotrexate + phenylalanine | - |
? | |
methotrexate-phenylalanine + H2O | prodrug activation in SW122 cells | Homo sapiens | methotrexate + phenylalanine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CPA | - |
Homo sapiens |