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Literature summary for 3.4.17.1 extracted from
- Secondary binding site of the potato carboxypeptidase inhibitor. Contribution to its structure, folding, and biological properties (2004), Biochemistry, 43, 7973-7982.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| potato carboxypeptidase inhibitor | i.e. PCI, wild-type and several mutants, oxidative folding, hydrogen exchange, and conformational stability, overview, secondary contact binding site structure and mechanism dependent, recombinant expression of the inhibitor protein in Escherichia coli, overview, steady-state binding kinetics | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-(4-methoxyphenylazoformyl)-L-phenylalanine + H2O | - |
Bos taurus | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CPA | - |
Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Bos taurus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000014 | - |
potato carboxypeptidase inhibitor mutant S30A | pH 7.5 | Bos taurus | |
| 0.0000015 | - |
potato carboxypeptidase inhibitor mutant N29A | pH 7.5 | Bos taurus | |
| 0.0000016 | - |
wild-type potato carboxypeptidase inhibitor | pH 7.5 | Bos taurus | |
| 0.0000019 | - |
potato carboxypeptidase inhibitor mutant N29A/S30A | pH 7.5 | Bos taurus | |
| 0.0000023 | - |
potato carboxypeptidase inhibitor mutant H15A | pH 7.5 | Bos taurus | |
| 0.0000035 | - |
potato carboxypeptidase inhibitor mutant N29G | pH 7.5 | Bos taurus | |
| 0.0000079 | - |
potato carboxypeptidase inhibitor mutant W22A | pH 7.5 | Bos taurus | |
| 0.0000132 | - |
potato carboxypeptidase inhibitor mutant W28A | pH 7.5 | Bos taurus | |
| 0.0000185 | - |
potato carboxypeptidase inhibitor mutant F23A | pH 7.5 | Bos taurus | |
| 0.00044 | - |
potato carboxypeptidase inhibitor mutant F23A/W28A | pH 7.5 | Bos taurus |
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