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Literature summary for 3.4.17.1 extracted from

  • Mock, W.L.; Cheng, H.
    Principles of hydroxamate inhibition of metalloproteases: carboxypeptidase A (2000), Biochemistry, 39, 13945-13952.
    View publication on PubMed
Search for more literature for 3.4.17.1

Inhibitors

Inhibitors Comment Organism Structure
2-(1-hydroxy-5-oxopyrrolidin-2-yl)-3-phenylpropanoic acid
-
 Bos taurus
2-benzyl-3-[(difluoroacetyl)(hydroxy)amino]propanoic acid
-
 Bos taurus
2-benzyl-3-[(fluoroacetyl)(hydroxy)amino]propanoic acid
-
 Bos taurus
2-benzyl-3-[formyl(hydroxy)amino]propanoic acid
-
 Bos taurus
2-benzyl-3-[hydroxy(methoxyacetyl)amino]propanoic acid
-
 Bos taurus
2-benzyl-3-[hydroxy(methoxycarbonyl)amino]propanoic acid
-
 Bos taurus
2-benzyl-3-[hydroxy(trifluoroacetyl)amino]propanoic acid
-
 Bos taurus
3-[acetyl(hydroxy)amino]-2-benzylpropanoic acid
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anisylazoformyl-L-Phe + H2O
-
 Bos taurus anisylazoformic acid + L-Phe
-
 ?
N-[3-(2-furyl)]acryloyl-L-Phe-L-Phe + H2O
-
 Bos taurus N-[3-(2-furyl)]acryloyl-L-Phe + L-Phe
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00139
-
 2-benzyl-3-[formyl(hydroxy)amino]propanoic acid 25°C, limiting value for Ki-value at intermediate pH Bos taurus
0.00259
-
 2-benzyl-3-[(difluoroacetyl)(hydroxy)amino]propanoic acid 25°C, limiting value for Ki-value at intermediate pH Bos taurus
0.00529
-
 2-(1-hydroxy-5-oxopyrrolidin-2-yl)-3-phenylpropanoic acid 25°C, limiting value for Ki-value at intermediate pH Bos taurus
0.00806
-
 3-[acetyl(hydroxy)amino]-2-benzylpropanoic acid 25°C, limiting value for Ki-value at intermediate pH Bos taurus
0.009
-
 2-benzyl-3-[hydroxy(methoxyacetyl)amino]propanoic acid 25°C, limiting value for Ki-value at intermediate pH Bos taurus
0.00942
-
 2-benzyl-3-[hydroxy(trifluoroacetyl)amino]propanoic acid 25°C, limiting value for Ki-value at intermediate pH Bos taurus
0.012
-
 2-benzyl-3-[(fluoroacetyl)(hydroxy)amino]propanoic acid 25°C, limiting value for Ki-value at intermediate pH Bos taurus
0.0994
-
 2-benzyl-3-[hydroxy(methoxycarbonyl)amino]propanoic acid 25°C, limiting value for Ki-value at intermediate pH Bos taurus