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Literature summary for 3.4.16.6 extracted from

  • Hu, Z.; Zhang, H.; Haley, B.; Macchi, F.; Yang, F.; Misaghi, S.; Elich, J.; Yang, R.; Tang, Y.; Joly, J.C.; Snedecor, B.R.; Shen, A.
    Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells (2016), Biotechnol. Bioeng., 113, 2100-2106 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Cricetulus griseus G3HR95
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Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
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 Cricetulus griseus
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Synonyms

Synonyms Comment Organism
CPD
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 Cricetulus griseus

General Information

General Information Comment Organism
physiological function CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells. Knockdown of CpD by RNAi increases C-terminal lysine levels of antibodies, whereas there is no obvious change in C-terminal lysine levels when carboxypeptidase CpM, CpN, CpB, or CpE is knocked downIn a CpD knockout mutant, C-terminal lysine cleavage is completely abolished Cricetulus griseus