Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | Scpep1 has carboxypeptidase activity against endothelin ET-1 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Scpep1 has carboxypeptidase activity against endothelin ET-1 | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Scpep1 | - |
Mus musculus |
serine carboxypeptidase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mice with a double CathA/Scpep1 deficiency (DD mice) demonstrate hypertension, increased ET-1-induced vasoconstriction and prolonged half-life of circulating ET-1 as compared to both wild-type animals and those with single CathA or Scpep1 deficiencies | Mus musculus |
physiological function | SCEP1 complements CathA action towards endothelin ET-1 | Mus musculus |
physiological function | Scpep1 and CathA together participate in the control of endothelin ET-1 regulation of vascular tone and hemodynamics | Mus musculus |