Literature summary for 3.4.16.5 extracted from

Schreuder, H.A.; Liesum, A.; Kroll, K.; Boehnisch, B.; Buning, C.; Ruf, S.; Sadowski, T.
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases (2014), Biochem. Biophys. Res. Commun., 445, 451-456.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli as a His-tagged fusion protein	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structures show that the structure of mature Cathepsin A is identical to the structure of the precursor and that activation depends solely on the removal/disorder transition of the activation domain. The active catalytic domain is held together by a strategically located disulfide bridge, linking the loose ends that are formed after removal/disorder transition of the activation domain	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P10619	-	-

Purification (Commentary)

Purification (Comment)	Organism
purified by metal-chelate and gel-filtration chromatography	Homo sapiens

Synonyms

Synonyms	Comment	Organism
cathepsin A	-	Homo sapiens

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Release 2023.1 (January 2023)