Cloned (Comment) | Organism |
---|---|
a soluble fragment of Pbp4 lacking the putative membrane anchor of the protein is expressed in Escherichia coli | Corynebacterium jeikeium |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ampicillin | complete inhibition at 0.57 mM, 95% inhibition at 0.285 mM | Corynebacterium jeikeium |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corynebacterium jeikeium | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GlcNAc-MurNAc-L-Ala-D-iGluNH2-meso-diaminopimelic acid-NH2-D-Ala-D-Ala + H2O | - |
Corynebacterium jeikeium | GlcNAc-MurNAc-L-Ala-D-iGluNH2-meso-diaminopimelic acid-NH2-D-Ala + D-Ala | - |
? | |
additional information | the enzyme cleaves the C-terminal D-Ala5 of stem pentapeptides and forms the essential tetrapeptide substrate of a beta-lactam-insensitive L,D-transpeptidase | Corynebacterium jeikeium | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D,D-carboxypeptidase | - |
Corynebacterium jeikeium |
PBP4 | - |
Corynebacterium jeikeium |
penicillin-binding protein | - |
Corynebacterium jeikeium |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.06 | - |
- |
Corynebacterium jeikeium | ampicillin |
General Information | Comment | Organism |
---|---|---|
physiological function | the beta-lactam-sensitive D,D-carboxypeptidase activity of Pbp4 controls the L,D and D,D transpeptidation pathways in Corynebacterium jeikeium | Corynebacterium jeikeium |