Application | Comment | Organism |
---|---|---|
medicine | PBP1b could be a target for antibacterial agents | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
for expression in Escherichia coli BL21DE3 cells | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Moenomycin | inhibits the glycosyl transferase activity | Escherichia coli | |
Vancomycin | vancomycin derivatives inhibit the glycosyl transferase activity | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Escherichia coli | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | the glycosyl transferase of PBP1b catalyzes the assembly of lipid-transported N-acetylglucosaminyl-beta-1,4-N-acetylmuramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala-D-Ala units | additional information | linear peptidoglycan chains | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
using Ni-NTA affinity chromatography | Escherichia coli |
Storage Stability | Organism |
---|---|
-20°C, Tris-HCl buffer, pH 7.5, 0.7% CHAPS, 0.5 M NaCl | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the glycosyl transferase of PBP1b catalyzes the assembly of lipid-transported N-acetylglucosaminyl-beta-1,4-N-acetylmuramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala-D-Ala units | Escherichia coli | additional information | linear peptidoglycan chains | ? |
Synonyms | Comment | Organism |
---|---|---|
PBP1b | - |
Escherichia coli |
penicillin-binding protein 1B | - |
Escherichia coli |