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Literature summary for 3.4.16.2 extracted from

  • Wallingford, N.; Perroud, B.; Gao, Q.; Coppola, A.; Gyengesi, E.; Liu, Z.W.; Gao, X.B.; Diament, A.; Haus, K.A.; Shariat-Madar, Z.; Mahdi, F.; Wardlaw, S.L.; Schmaier, A.H.; Warden, C.H.; Diano, S.
    Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents (2009), J. Clin. Invest., 119, 2291-2303.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.16.2

Inhibitors

Inhibitors Comment Organism Structure
N-benzyloxycarbonyl-prolyl-prolinal the inhibition of PRCP activity by small molecule protease inhibitors administered peripherally or centrally decreased food intake in both wild-type and obese mice Mus musculus
t-butyl carbamate-prolyl-prolinal the inhibition of PRCP activity by small molecule protease inhibitors administered peripherally or centrally decreased food intake in both wild-type and obese mice Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000
-
 predicted molecular mass of recombinant PRCP Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-melanocyte-stimulating hormone + H2O Mus musculus using recombinant PRCP it is shown that PRCP removes the C-terminal amino acid of alpha-melanocyte-stimulating hormone1-13, producing alpha-melanocyte-stimulating hormone1-12, which is not neuroactive ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
hypothalamus Prcp is expressed in the hypothalamus in neuronal populations that send efferents to areas where alpha-melanocyte-stimulating hormone1-13 is released from axon terminals Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-melanocyte-stimulating hormone + H2O using recombinant PRCP it is shown that PRCP removes the C-terminal amino acid of alpha-melanocyte-stimulating hormone1-13, producing alpha-melanocyte-stimulating hormone1-12, which is not neuroactive Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
PRCP
-
 Mus musculus
prolylcarboxypeptidase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction Prcp-null mice have elevated levels of alpha-melanocyte-stimulating hormone 1-13 in the hypothalamus and aree leaner and shorter than the wild-type controls on a regular chow diet. They are also resistant to high-fat diet-induced obesity Mus musculus
physiological function PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-melanocyte-stimulating hormone1-13 levels Mus musculus