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Literature summary for 3.4.16.2 extracted from
- Reduced levels of neurotransmitter-degrading enzyme PRCP promote obesity (2009), J. Clin. Invest., 119, 2130-2133.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-melanocyte-stimulating hormone + H2O | Mus musculus | evidence is provided that in mice, PRCP degrades alpha-melanocyte-stimulating hormone to an inactive form that is unable to inhibit food intake | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q7TMR0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| hypothalamus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-melanocyte-stimulating hormone + H2O | evidence is provided that in mice, PRCP degrades alpha-melanocyte-stimulating hormone to an inactive form that is unable to inhibit food intake | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PRCP | - |
Mus musculus |
| prolylcarboxypeptidase | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | Prcp-null (Prcp-/-) mice eat less and have even less fat than the mice with partial loss of the enzyme. Knockout mice are resistant to diet-induced obesity | Mus musculus |
| physiological function | PRCP expression promotes obesity, while inhibitors of the enzyme counteract obesity | Mus musculus |
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Release 2023.1 (January 2023)
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