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Literature summary for 3.4.15.1 extracted from

  • Nishimura, K.; Yoshida, N.; Hiwada, K.; Ueda, E.; Kokubu, T.
    Properties of three different forms of angiotensin I-converting enzyme from human lung (1978), Biochim. Biophys. Acta, 522, 229-237.
    View publication on PubMed
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
angiotensin II
-
 Homo sapiens
Arg-Pro-Pro inhibition of enzyme form I and II, enzyme form III is not inhibited Homo sapiens
bradykinin
-
 Homo sapiens
bradykinin potentiator C inhibition of enzyme form I and II, enzyme form III is not inhibited Homo sapiens
EDTA
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.6
-
 hippuryl-His-Leu 100 mM borate/sodium carbonate buffer, pH 7.8 Homo sapiens
1.1
-
 hippuryl-His-Leu 10 mM potassium phosphate buffer, pH 8.3, enzyme form I, II, and III Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
98000
-
 enzyme form III, gel filtration Homo sapiens
180000
-
 enzyme form II, gel filtration Homo sapiens
290000
-
 enzyme form I, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
lung 3 different enzyme forms: I, II, and III Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Homo sapiens angiotensin II + His-Leu
-
 ?
bradykinin + H2O
-
 Homo sapiens Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
hippuryl-His-Leu + H2O
-
 Homo sapiens hippuric acid + His-Leu
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 10 min, enzyme form I and II lose 90% of the hydrolytic activity with hippuryl-His-Leu as substrate, enzyme form III loses 45% of its activity Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3 8 hydrolysis of hippuryl-His-Leu, borate/sodium carbonate buffer Homo sapiens