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Literature summary for 3.4.15.1 extracted from
- Catalysis of angiotensin I hydrolysis by human angiotensin-converting enzyme: effect of chloride and pH (1988), Biochemistry, 27, 5538-5544.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Cl- | nonessential activator over the pH range 5.0-10.0 | Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Km for angiotensin I as a function of pH | Homo sapiens | |
| 0.21 | - |
angiotensin I | pH 7.5, 0.2 mM NaCl | Homo sapiens | |
| 0.42 | - |
angiotensin I | pH 9.0, 0.5 mM NaCl | Homo sapiens | |
| 0.54 | - |
angiotensin I | pH 6.0, without NaCl | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Km-values for angiotensin I as a function of pH | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.1 | - |
without Cl- | Homo sapiens |
| 7.6 | - |
at 400 mM NaCl | Homo sapiens |
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