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Literature summary for 3.4.15.1 extracted from

  • Stewart, T.A.; Weare, J.A.; Erdös, E.G.
    Human peptidyl dipeptidase (converting enzyme, kininase II) (1981), Methods Enzymol., 80, 450-460.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Cl- required Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
captopril
-
Homo sapiens
EDTA
-
Homo sapiens
snake venom peptide
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.6
-
benzoyl-Gly-Phe-Arg
-
Homo sapiens
1.3
-
benzoyl-Gly-His-Leu
-
Homo sapiens
6.2
-
benzoyl-Gly-Gly-Gly
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
155000
-
enzyme from serum, sucrose density gradient centrifugation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification enzyme from lung and kidney contains similar amounts of N-acetylglucosamine, mannose, galactose and fucose. The lung enzyme contains significantly more sialic acid Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
lung
-
Homo sapiens
-
serum
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
32
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, pH 7.0, 0.01 M KH2PO4/K2HPO4, 0.5 M NaCl, stable for several months Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Homo sapiens angiotensin II + His-Leu
-
?
benzoyl-Gly-Gly-Gly + H2O
-
Homo sapiens benzoyl-Gly + Gly-Gly
-
?
benzoyl-Gly-His-Leu + H2O
-
Homo sapiens benzoyl-Gly + His-Leu
-
?
benzoyl-Gly-Phe-Arg + H2O
-
Homo sapiens benzoyl-Gly + Phe-Arg
-
?
bradykinin + H2O
-
Homo sapiens Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
?

Subunits

Subunits Comment Organism
monomer 1 * 155000, enzyme from kidney and lung, SDS-PAGE in presence of 2-mercaptoethanol Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
76.7
-
benzoyl-Gly-His-Leu
-
Homo sapiens
283
-
benzoyl-Gly-Gly-Gly
-
Homo sapiens
383
-
benzoyl-Gly-Phe-Arg
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
at 0.1 M NaCl, substrate benzoyl-Gly-Gly-Gly Homo sapiens
7.6
-
at 1.0 mM NaCl, substrate benzoyl-Gly-Gly-Gly Homo sapiens