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Literature summary for 3.4.15.1 extracted from

  • Takagaki, A.; Nanjo, F.
    Effects of metabolites produced from (-)-epigallocatechin gallate by rat intestinal bacteria on angiotensin I-converting enzyme activity and blood pressure in spontaneously hypertensive rats (2015), J. Agric. Food Chem., 63, 8262-8266 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(-)-epigallocatechin gallate
-
Rattus norvegicus
5-(3,4,5-trihydroxyphenyl) 4-hydroxyvaleric acid
-
Rattus norvegicus
5-(3,4,5-trihydroxyphenyl)-gamma-valerolactone the metabolite has a hypotensive effect in vivo Rattus norvegicus
5-(3,5-dihydroxyphenyl) 4-hydroxyvaleric acid
-
Rattus norvegicus
5-(3,5-dihydroxyphenyl)-gamma-valerolactone the metabolite has a hypotensive effect in vivo Rattus norvegicus
additional information effects of metabolites produced from (-)-epigallocatechin gallate by rat intestinal bacteria on angiotensin I-converting enzyme activity and blood pressure in spontaneously hypertensive rats. All of the metabolites show ACE inhibitory activities and the order of IC50 is hydroxyphenyl valeric acids > 5-(3,4,5-trihydroxyphenyl)-gamma-valerolactone > 5-(3,4,5-trihydroxyphenyl) 4-hydroxyvaleric acid >> 5-(3,5-dihydroxyphenyl) 4-hydroxyvaleric acid >> 5-(3,5-dihydroxyphenyl)-gamma-valerolactone. Among the catechins, galloylated catechins exhibit stronger ACE inhibitory activity than nongalloylated catechins. Measurement of systolic blood pressure (SBP) after oral administration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Rattus norvegicus
-
angiotensin II + L-His-L-Leu
-
?
angiotensin I + H2O Rattus norvegicus Wistar
-
angiotensin II + L-His-L-Leu
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P47820 spontaneously hypertensive rats, SHR
-
Rattus norvegicus Wistar P47820 spontaneously hypertensive rats, SHR
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Rattus norvegicus angiotensin II + L-His-L-Leu
-
?
angiotensin I + H2O
-
Rattus norvegicus Wistar angiotensin II + L-His-L-Leu
-
?

Synonyms

Synonyms Comment Organism
ACE
-
Rattus norvegicus
angiotensin I-converting enzyme
-
Rattus norvegicus