Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme inhibition kinetics and moelecular docking of patatin-derived peptides. The higher inhibitory potency of PRY might be attributed to formation of more hydrogen bonds with the enzyme's active site or non-active sites that distort the configuration necessary for catalysis | Oryctolagus cuniculus | |
Pro-Arg-Tyr | a potato patatin-derived peptide, competitive inhibition | Oryctolagus cuniculus | |
Trp-Gly | a potato patatin-derived peptide, mixed-type inhibition | Oryctolagus cuniculus | |
Trp-Tyr-Thr | a peptide from hempseed, mixed-type inhibition | Oryctolagus cuniculus | |
Trp-Val-Tyr-Tyr | a peptide from hempseed, mixed-type inhibition | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Oryctolagus cuniculus | - |
angiotensin II + L-His-L-Leu | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | P12822 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | from lung with 98% purity | Oryctolagus cuniculus | - |
lung | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Oryctolagus cuniculus | angiotensin II + L-His-L-Leu | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Oryctolagus cuniculus |
angiotensin I-converting enzyme | - |
Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Oryctolagus cuniculus | |
0.02825 | - |
Pro-Arg-Tyr | pH and temperature not specified in the publication | Oryctolagus cuniculus | |
0.20027 | - |
Trp-Gly | pH and temperature not specified in the publication | Oryctolagus cuniculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.09533 | - |
pH and temperature not specified in the publication | Oryctolagus cuniculus | Pro-Arg-Tyr | |
0.11234 | - |
pH and temperature not specified in the publication | Oryctolagus cuniculus | Trp-Gly |