Literature summary for 3.4.15.1 extracted from

Fu, Y.; Alashi, A.M.; Young, J.F.; Therkildsen, M.; Aluko, R.E.
Enzyme inhibition kinetics and molecular interactions of patatin peptides with angiotensin I-converting enzyme and renin (2017), Int. J. Biol. Macromol., 101, 207-213 .

Search for more literature for 3.4.15.1

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	enzyme inhibition kinetics and moelecular docking of patatin-derived peptides. The higher inhibitory potency of PRY might be attributed to formation of more hydrogen bonds with the enzyme's active site or non-active sites that distort the configuration necessary for catalysis	Oryctolagus cuniculus
Pro-Arg-Tyr	a potato patatin-derived peptide, competitive inhibition	Oryctolagus cuniculus
Trp-Gly	a potato patatin-derived peptide, mixed-type inhibition	Oryctolagus cuniculus
Trp-Tyr-Thr	a peptide from hempseed, mixed-type inhibition	Oryctolagus cuniculus
Trp-Val-Tyr-Tyr	a peptide from hempseed, mixed-type inhibition	Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensin I + H2O	Oryctolagus cuniculus	-	angiotensin II + L-His-L-Leu	-	?

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	P12822	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	from lung with 98% purity	Oryctolagus cuniculus	-
lung	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensin I + H2O	-	Oryctolagus cuniculus	angiotensin II + L-His-L-Leu	-	?

Synonyms

Synonyms	Comment	Organism
ACE	-	Oryctolagus cuniculus
angiotensin I-converting enzyme	-	Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	inhibition kinetics	Oryctolagus cuniculus
0.02825	-	Pro-Arg-Tyr	pH and temperature not specified in the publication	Oryctolagus cuniculus
0.20027	-	Trp-Gly	pH and temperature not specified in the publication	Oryctolagus cuniculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.09533	-	pH and temperature not specified in the publication	Oryctolagus cuniculus	Pro-Arg-Tyr
0.11234	-	pH and temperature not specified in the publication	Oryctolagus cuniculus	Trp-Gly

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Release 2023.1 (January 2023)