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Literature summary for 3.4.15.1 extracted from

  • Jimsheena, V.K.; Gowda, L.R.
    Arachin derived peptides as selective angiotensin I-converting enzyme (ACE) inhibitors: structure-activity relationship (2010), Peptides, 31, 1165-1176.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
enalapril i.e. (2S)-1-[(2S)-2-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aminopropanoyl]pyrrolidine-2-carboxylic acid Homo sapiens
enalapril i.e. (2S)-1-[(2S)-2-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aminopropanoyl]pyrrolidine-2-carboxylic acid Sus scrofa
Ile-Glu-Pro molecular docking analysis at the active site of testis ACE, overview Homo sapiens
Ile-Glu-Pro
-
Sus scrofa
Ile-Glu-Trp
-
Homo sapiens
Ile-Glu-Trp
-
Sus scrofa
Ile-Glu-Tyr molecular docking analysis at the active site of testis ACE, overview Homo sapiens
Ile-Glu-Tyr
-
Sus scrofa
Ile-Lys-Pro a potent competitive inhibitor, molecular docking analysis at the active site of testis ACE, overview Homo sapiens
Ile-Lys-Pro
-
Sus scrofa
Ile-Lys-Trp molecular docking analysis at the active site of testis ACE, overview Homo sapiens
Ile-Lys-Trp
-
Sus scrofa
Ile-Lys-Tyr molecular docking analysis at the active site of testis ACE, overview Homo sapiens
Ile-Lys-Tyr
-
Sus scrofa
lisinopril i.e. N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline, molecular docking analysis at the active site of testis ACE, PDB ID 1086, overview Homo sapiens
lisinopril i.e. N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline Sus scrofa
additional information inhibitory potencies of tripeptides derived from arachin, the major storage globulin of peanut, Arachis hypogaea variety TMV-2, sequence analysis, overview. Active site biniding and the degree of inhibition by the peptides correlates with the coordination distance between the catalytic Zn2+ and the carbonyl oxygen of the peptide bond between the amino-terminal and middle residue Homo sapiens
additional information inhibitory potencies of tripeptides derived from arachin, the major storage globulin of peanut, Arachis hypogaea variety TMV-2, sequence analysis, overview. Active site biniding and the degree of inhibition by the peptides correlates with the coordination distance between the catalytic Zn2+ and the carbonyl oxygen of the peptide bond between the amino-terminal and middle residue. In vitro stability of the peptides to gastrointestinal proteases, overview Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ catalytically important Homo sapiens
Zn2+ catalytically important Sus scrofa

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-
lung
-
Sus scrofa
-
testis germinal isozyme Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hippuryl-His-Leu + H2O colorimetric assay method Homo sapiens hippuric acid + His-Leu
-
?
hippuryl-His-Leu + H2O colorimetric assay method Sus scrofa hippuric acid + His-Leu
-
?

Synonyms

Synonyms Comment Organism
ACE
-
Homo sapiens
ACE
-
Sus scrofa
angiotensin I-converting enzyme
-
Homo sapiens
angiotensin I-converting enzyme
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2
-
assay at Homo sapiens
8.2
-
assay at Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000001
-
lisinopril
-
Homo sapiens
0.0027
-
Ile-Lys-Pro
-
Homo sapiens
0.0072
-
Ile-Glu-Pro
-
Homo sapiens
0.0085
-
Ile-Lys-Trp
-
Homo sapiens
0.013
-
Ile-Lys-Tyr
-
Homo sapiens
0.055
-
Ile-Glu-Trp
-
Homo sapiens
0.0835
-
Ile-Glu-Tyr
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.007
-
-
Sus scrofa Ile-Lys-Pro
0.018
-
-
Sus scrofa Ile-Glu-Pro
0.019
-
-
Sus scrofa Ile-Lys-Trp
0.034
-
-
Sus scrofa Ile-Lys-Tyr
0.104
-
-
Sus scrofa Ile-Glu-Trp
0.182
-
-
Sus scrofa Ile-Glu-Tyr