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Literature summary for 3.4.15.1 extracted from

  • Abd Alla, J.; Langer, A.; Elzahwy, S.S.; Arman-Kalcek, G.; Streichert, T.; Quitterer, U.
    Angiotensin-converting enzyme (ACE) inhibition down regulates the pro-atherogenic chemokine receptor 9 (CCR9) - chemokine ligand 25 (CCL25) axis (2010), J. Biol. Chem., 285, 23496-23505.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
captopril microarray gene expression profiling of the aorta during atherosclerosis prevention with the ACE inhibitor, overview. Captopril treatment for 7 months strongly decreases the recruitment of proatherogenic immune cells into the aorta. Captopril-mediated inhibition of plaque infiltrating immune cells involves downregulation of the C-C chemokine receptor 9, CCR9, phenotype and physiological mechanism, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Mus musculus
-
angiotensin II + His-Leu
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
atherosclerosis-prone apolipoprotein E-deficient C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Mus musculus angiotensin II + His-Leu
-
?

Synonyms

Synonyms Comment Organism
ACE
-
Mus musculus
angiotensin-converting enzyme
-
Mus musculus

General Information

General Information Comment Organism
malfunction atherosclerosis-enhancing effects of angiotensin II Mus musculus