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Literature summary for 3.4.15.1 extracted from

  • Kwon, E.K.; Lee, D.Y.; Lee, H.; Kim, D.O.; Baek, N.I.; Kim, Y.E.; Kim, H.Y.
    Flavonoids from the buds of Rosa damascena inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase and angiotensin I-converting enzyme (2010), J. Agric. Food Chem., 58, 882-886.
    View publication on PubMed
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
captopril
-
 Oryctolagus cuniculus
cyanidin-3-O-beta-D-glucoside isolated from flower buds of Rosa damascena. Metal ions might be involved in the inhibition Oryctolagus cuniculus
additional information no inhibition by flavonoid glycosides, isolated from flower buds of Rosa damascena, kaempferol-3-O-beta-D-glucopyranosyl-(1,4)-beta-D-xylopyranoside, i.e. roxyloside A, isoquercitrin, quercetin gentiobioside, and afzelin Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Oryctolagus cuniculus
-
lung
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hippuryl-His-Leu + H2O
-
 Oryctolagus cuniculus hippuric acid + His-Leu
-
 ?

Synonyms

Synonyms Comment Organism
ACE
-
 Oryctolagus cuniculus
angiotensin I-converting enzyme
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
 assay at Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000092
-
 pH 8.3, 37°C Oryctolagus cuniculus captopril
0.1388
-
 pH 8.3, 37°C Oryctolagus cuniculus cyanidin-3-O-beta-D-glucoside