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Literature summary for 3.4.15.1 extracted from

  • Katayama, K.; Anggraeni, H.E.; Mori, T.; Ahhmed, A.M.; Kawahara, S.; Sugiyama, M.; Nakayama, T.; Maruyama, M.; Muguruma, M.
    Porcine skeletal muscle troponin is a good source of peptides with Angiotensin-I converting enzyme inhibitory activity and antihypertensive effects in spontaneously hypertensive rats (2008), J. Agric. Food Chem., 56, 355-360.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
EKERERQ
-
Rattus norvegicus
KRQKYDI competitive inhibitor, the strongest inhibitor among reported troponin-originated peptides. The inhibhitor is slowly hydrolyzed by treatment with angiotensin I-converting enzyme. When KRQKYDI is administered orally to spontaneously hypertensive rats at a dose of 10 mg/kg, a temporary antihypertensive activity is observed at 3 and 6 h after administration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
spontaneously hypertensive rats
-

Source Tissue

Source Tissue Comment Organism Textmining

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0262
-
-
Rattus norvegicus KRQKYDI
0.552
-
-
Rattus norvegicus EKERERQ