Literature summary for 3.4.15.1 extracted from

Nikolaeva, M.A.; Balyasnikova, I.V.; Alexinskaya, M.A.; Metzger, R.; Franke, F.E.; Albrecht, R.F.2nd.; Kulakov, V.I.; Sukhikh, G.T.; Danilov, S.M.
Testicular isoform of angiotensin I-converting enzyme (ACE, CD143) on the surface of human spermatozoa: revelation and quantification using monoclonal antibodies (2006), Am. J. Reprod. Immunol., 55, 54-68.

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Application

Application	Comment	Organism
medicine	monoclonal antibodies recognizing the C-terminal domain of human ACE are useful tools for quantification of testicular isoform of angiotensin I-converting enzyme expression on human live and fixed spermatozoa and further adequate analysis of the tACE role in reproduction. The development of adequate quantitative assays of expression of the testicular isoform of angiotensin I-converting enzyme on the surface of ejaculated spermatozoa might be important for further studies about the role of the enzyme in male fertility	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	-	Homo sapiens	9986	-
plasma membrane	testicular ACE is located in the plasma membrane of the post-acrosomal region, the neck and midpiece of normal spermatozoa, but shows a variable distribution on the defective cells	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spermatozoon	-	Homo sapiens	-
spermatozoon	testicular ACE is located in the plasma membrane of the post-acrosomal region, the neck and midpiece of normal spermatozoa, but shows a variable distribution on the defective cells	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CD143	-	Homo sapiens
testicular ACE	-	Homo sapiens

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Release 2023.1 (January 2023)