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Literature summary for 3.4.14.9 extracted from

  • Petrova, E.B.; Dimitrova, M.B.; Ivanov, I.P.; Pavlova, V.G.; Dimitrova, S.G.; Kadiysky, D.S.
    Effect of acute hypoxic shock on the rat brain morphology and tripeptidyl peptidase I activity (2016), Acta Histochem., 118, 496-504 .
    View publication on PubMed
Search for more literature for 3.4.14.9

Inhibitors

Inhibitors Comment Organism Structure
L-alanyl-L-alanyl-L-phenylalanyl-chloromethyl ketone AAF-CMK Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Q9EQV6 isoform TPP1
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebellar cortex
-
 Rattus norvegicus
-
cerebellar Purkinje cell
-
 Rattus norvegicus
-
cerebral cortex
-
 Rattus norvegicus
-
medulla oblongata
-
 Rattus norvegicus
-
midbrain
-
 Rattus norvegicus
-
additional information morphological changes in the studied brain parts at different time periods following a single i.p. injection of sodium nitrite and altered TPPI activity in the brain, immunohistochemic analysis of the enzyme in brain regions and different neurons, overview Rattus norvegicus
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neuron
-
 Rattus norvegicus
-
pons
-
 Rattus norvegicus
-
thalamus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro-L-Met-L-anthraquinonyl hydrazide + H2O
-
 Rattus norvegicus ?
-
 ?
L-Asp-L-Ala-L-Phe-4-nitroanilide + H2O
-
 Rattus norvegicus L-Asp-L-Ala-L-Phe + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
Tpp1
-
 Rattus norvegicus
TPPI
-
 Rattus norvegicus
tripeptidyl peptidase I
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
 assay at Rattus norvegicus

General Information

General Information Comment Organism
physiological function in sodium nitrite-induced acute hypoxic shocked rat brain, morphological changes in cerebral cortex, cerebellum, medulla oblongata, thalamus,mesencephalon and pons are assessed using silver-copper impregnation for neurodegeneration. TPPI activity on these brains leads to less vulnerable to oxidative stress, the studied brain areas show different histopathological changes, such as neuronal loss and tissue vacuolization, dilatation of the smallest capillaries and impairment of neuronal processes. TPPI activity is strictly regulated following the hypoxic stress. The involvement of the enzyme in rat brain response to hypoxic stress causes a temporary enzyme deficiency in all types of neurons Rattus norvegicus
physiological function upon hypoxic shock, the studied brain areas show different histopathological changes, such as neuronal loss and tissue vacuolization, dilatation of the smallest capillaries and impairment of neuronal processes. TPPI activity is strictly regulated following the hypoxic stress. TPPI activity increases 12-24 h post-treatment, then decreases followed by a slow process of recovery. There is a temporary enzyme deficiency in all types of neurons Rattus norvegicus