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Literature summary for 3.4.14.5 extracted from

  • Sato, K.; Nakamura, A.; Shirakawa, J.; Muraoka, T.; Togashi, Y.; Shinoda, K.; Orime, K.; Kubota, N.; Kadowaki, T.; Terauchi, Y.
    Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and beta-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet (2012), Endocrinology, 153, 1093-1102.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
vildagliptin vildagliptin improves glucose tolerance and increases the beta-cell mass by reducing beta-cell apoptosis in Insulin Receptor Substrate-2-Knockout mice fed a high-fat diet, and the reduction of beta-cell apoptosis by vildagliptin is independent of the Insulin Receptor Substrate-2 expression in the cells Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P28843
-
-

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase-4
-
Mus musculus
DPP-4
-
Mus musculus

General Information

General Information Comment Organism
physiological function inhibition of enzyme by vildagliptin improves glucose tolerance and increases the beta-cell mass by reducing beta-cell apoptosis in Insulin Receptor Substrate-2-knockout mice fed a high-fat diet, and the reduction of beta-cell apoptosis by vildagliptin is independent of the Insulin Receptor Substrate-2 expression in the cells Mus musculus