Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-6-(trifluoromethyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide, to 3.2 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-6-(trifluoromethyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide | good enzyme inhibitory activity and excellent selectivity for isoform DPP4 over dipeptidyl peptidase family homologues DPP8 and DPP9. Compound shows efficacy similar to that of sitagliptin in the oral glucose tolerance test | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
104400 | - |
x * 104400, mass spectrometry, x * 110000, SDS-PAGE | Homo sapiens |
110000 | - |
x * 104400, mass spectrometry, x * 110000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | glycosylation can be estimated to account for 24% of the molecular mass of the whole glycosylated protein | Homo sapiens |
Subunits | Comment | Organism |
---|---|---|
? | x * 104400, mass spectrometry, x * 110000, SDS-PAGE | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000031 | - |
pH 7.5, temperature not specified in the publication | Homo sapiens | N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-6-(trifluoromethyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide |