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Literature summary for 3.4.14.5 extracted from

  • Sharma, M.; Singh, D.; Gupta, M.
    Synthesis and evaluation of thiouracil derivatives as dipeptidyl peptidase IV inhibitors (2013), Chem. Biol. Drug Des., 81, 257-264.
    View publication on PubMed
Search for more literature for 3.4.14.5

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-(2-[4-(4-chloro-phenyl)-piperazin-1-yl]-2-oxoethylsulfanyl)-4-hydroxy-6-phenyl-pyrimidine-5-carbonitrile single dose of 10 mg/kg of the compound significantly reduces glucose excursion during oral glucose tolerance test in streptozotocin-induced diabetic rat model Homo sapiens
2-([2-(4-aminopiperidin-1-yl)-2-oxoethyl]sulfanyl)-4-hydroxy-6-phenylpyrimidine-5-carbonitrile single dose of 10 mg/kg of the compound significantly reduces glucose excursion during oral glucose tolerance test in streptozotocin-induced diabetic rat model Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Gly-L-Pro + 7-amino-4-methylcoumarin
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00025
-
 pH not specified in the publication, 37°C Homo sapiens 2-([2-(4-aminopiperidin-1-yl)-2-oxoethyl]sulfanyl)-4-hydroxy-6-phenylpyrimidine-5-carbonitrile
0.00032
-
 pH not specified in the publication, 37°C Homo sapiens 2-(2-[4-(4-chloro-phenyl)-piperazin-1-yl]-2-oxoethylsulfanyl)-4-hydroxy-6-phenyl-pyrimidine-5-carbonitrile