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Literature summary for 3.4.14.5 extracted from

  • Luft, V.C.; Schmidt, M.I.; Pankow, J.S.; Hoogeveen, R.C.; Couper, D.; Heiss, G.; Duncan, B.B.; Duncan, B.B.
    Dipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study (2010), Diabetes Care, 33, 1109-1111.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
(2S,3S,11bS)-3-(1,1-dioxido-1,2-thiazinan-2-yl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Rattus norvegicus
(3S)-N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-fluoro-3-methylbutanamide
-
 Rattus norvegicus
1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-methylpiperidin-2-one
-
 Rattus norvegicus
1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-5-methylpiperidin-2-one
-
 Rattus norvegicus
1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]azepan-2-one
-
 Rattus norvegicus
1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]piperidin-2-one
-
 Rattus norvegicus
3-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-1,3-oxazinan-2-one
-
 Rattus norvegicus
carmegliptin potent and long-acting dipeptidyl peptidase IV inhibitor Rattus norvegicus
ethyl [(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]carbamate
-
 Rattus norvegicus
N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-2-methylbutanamide
-
 Rattus norvegicus
N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylbutanamide
-
 Rattus norvegicus
N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylpentanamide
-
 Rattus norvegicus
N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]butanamide
-
 Rattus norvegicus
N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]pentanamide
-
 Rattus norvegicus
N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]propane-1-sulfonamide
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
 Rattus norvegicus
DPP-IV
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000026
-
-
 Rattus norvegicus N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylbutanamide
0.0000036
-
-
 Rattus norvegicus (3S)-N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-fluoro-3-methylbutanamide
0.0000037
-
-
 Rattus norvegicus 1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-5-methylpiperidin-2-one
0.0000068
-
-
 Rattus norvegicus carmegliptin
0.0000093
-
-
 Rattus norvegicus N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylbutanamide
0.000013
-
-
 Rattus norvegicus N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylbutanamide
0.000013
-
-
 Rattus norvegicus N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylpentanamide
0.000019
-
-
 Rattus norvegicus 1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-methylpiperidin-2-one
0.000022
-
-
 Rattus norvegicus 1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]piperidin-2-one
0.000142
-
-
 Rattus norvegicus (2S,3S,11bS)-3-(1,1-dioxido-1,2-thiazinan-2-yl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.000142
-
-
 Rattus norvegicus 3-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-1,3-oxazinan-2-one
0.00043
-
-
 Rattus norvegicus 1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]azepan-2-one
0.00051
-
-
 Rattus norvegicus N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]butanamide
0.00115
-
-
 Rattus norvegicus ethyl [(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]carbamate
0.00133
-
-
 Rattus norvegicus N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]propane-1-sulfonamide
0.0022
-
-
 Rattus norvegicus N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]pentanamide
0.0078
-
-
 Rattus norvegicus 1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]piperidin-2-one
0.01
-
-
 Rattus norvegicus N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-2-methylbutanamide