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Literature summary for 3.4.14.5 extracted from

  • Kim, S.J.; Nian, C.; Doudet, D.J.; McIntosh, C.H.
    Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation (2009), Diabetes, 58, 641-651.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
MK0431 sitagliptin, treatment of NOD mice with daily 4 g/kg MK0431 before and after islet transplantation results in prolongation of islet graft survival Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Mus musculus
-
?
-
?
glucagon-like peptide 1 + H2O Mus musculus NOD/LtJ
-
?
-
?
glucose-dependent insulinotropic peptide + H2O Mus musculus
-
?
-
?
glucose-dependent insulinotropic peptide + H2O Mus musculus NOD/LtJ
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus NOD/LtJ
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
Mus musculus ?
-
?
glucagon-like peptide 1 + H2O
-
Mus musculus NOD/LtJ ?
-
?
glucose-dependent insulinotropic peptide + H2O
-
Mus musculus ?
-
?
glucose-dependent insulinotropic peptide + H2O
-
Mus musculus NOD/LtJ ?
-
?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
Mus musculus Gly-L-Pro + 7-amino-4-methylcoumarin
-
?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
Mus musculus NOD/LtJ Gly-L-Pro + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase-IV
-
Mus musculus
DPP-IV
-
Mus musculus