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Literature summary for 3.4.14.5 extracted from

  • Hu, C.X.; Huang, H.; Zhang, L.; Huang, Y.; Shen, Z.F.; Cheng, K.D.; Du, G.H.; Zhu, P.
    A new screening method based on yeast-expressed human dipeptidyl peptidase IV and discovery of novel inhibitors (2009), Biotechnol. Lett., 31, 979-984.
    View publication on PubMed
Search for more literature for 3.4.14.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris strain GS115 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-cyclohexyl-2-oxo-2-(1,3-thiazolidin-3-yl)ethanaminium 2,2,2-trifluoro-1-oxoethanide
-
 Homo sapiens
2-ethoxy-4-[2-(methylsulfanyl)ethyl]-1,3,2-oxazaphospholidine 2-sulfide
-
 Homo sapiens
4-[2-(methylsulfanyl)ethyl]-2-phenoxy-1,3,2-oxazaphospholidine 2-sulfide
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
 SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27487
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation and Sephacryl S-200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro-4-nitroanilide
-
 Homo sapiens Gly-L-Pro + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
 Homo sapiens
DPP-IV
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00046
-
-
 Homo sapiens 1-cyclohexyl-2-oxo-2-(1,3-thiazolidin-3-yl)ethanaminium 2,2,2-trifluoro-1-oxoethanide
0.0065
-
-
 Homo sapiens 2-ethoxy-4-[2-(methylsulfanyl)ethyl]-1,3,2-oxazaphospholidine 2-sulfide
0.0435
-
-
 Homo sapiens 4-[2-(methylsulfanyl)ethyl]-2-phenoxy-1,3,2-oxazaphospholidine 2-sulfide