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Literature summary for 3.4.14.5 extracted from

  • Chen, P.; Caldwell, C.G.; Mathvink, R.J.; Leiting, B.; Marsilio, F.; Patel, R.A.; Wu, J.K.; He, H.; Lyons, K.A.; Thornberry, N.A.; Weber, A.E.
    Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes (2007), Bioorg. Med. Chem. Lett., 17, 5853-5857.
    View publication on PubMed
Search for more literature for 3.4.14.5

Application

Application Comment Organism
medicine imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabete, pharmacokinetic properties Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(2-phenyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)butan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-[2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[(4R)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[(4S)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[1-(2-methylpropyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[1-(4-fluorobenzyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[1-ethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[2-(4-fluorophenyl)-1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[3-(2-methylpropyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[3-(4-fluorobenzyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[3-ethyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-1-(2,5-difluorophenyl)-4-[3-methyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
 Rattus norvegicus
(2R)-4-oxo-1-(2,4,5-trifluorophenyl)-4-[1,4,4-trimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4R)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4R)-2-cyclopropyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4R)-2-tert-butyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4R)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4R)-4-benzyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4R)-4-cyclopropyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4R)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4S)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4S)-2-cyclopropyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4S)-2-tert-butyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4S)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4S)-4-benzyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4S)-4-cyclopropyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[(4S)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus
(2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
 Rattus norvegicus
DPP-4
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000058
-
-
 Rattus norvegicus (2R)-4-[(4R)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.0000084
-
-
 Rattus norvegicus (2R)-4-[(4R)-4-benzyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.000045
-
-
 Rattus norvegicus (2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00005
-
-
 Rattus norvegicus (2R)-4-[(4R)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00006
-
-
 Rattus norvegicus (2R)-4-[(4R)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.000065
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[(4R)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00011
-
-
 Rattus norvegicus (2R)-4-[(4R)-4-cyclopropyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00013
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-oxo-4-(2-phenyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)butan-2-amine
0.00013
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[3-methyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00014
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-oxo-4-[2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-2-amine
0.00015
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00018
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[1-ethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00019
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[(4S)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00022
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[1-(2-methylpropyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00023
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[3-ethyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00025
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[1-(4-fluorobenzyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00025
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[3-(4-fluorobenzyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00025
-
-
 Rattus norvegicus (2R)-4-[(4R)-2-cyclopropyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00026
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[3-(2-methylpropyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00028
-
-
 Rattus norvegicus (2R)-1-(2,5-difluorophenyl)-4-[2-(4-fluorophenyl)-1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
0.00034
-
-
 Rattus norvegicus (2R)-4-[(4S)-4-cyclopropyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00037
-
-
 Rattus norvegicus (2R)-4-[(4R)-2-tert-butyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00038
-
-
 Rattus norvegicus (2R)-4-[(4S)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00049
-
-
 Rattus norvegicus (2R)-4-[(4S)-2-cyclopropyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00057
-
-
 Rattus norvegicus (2R)-4-oxo-1-(2,4,5-trifluorophenyl)-4-[1,4,4-trimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-2-amine
0.00057
-
-
 Rattus norvegicus (2R)-4-[(4S)-4-benzyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00061
-
-
 Rattus norvegicus (2R)-4-[(4S)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00063
-
-
 Rattus norvegicus (2R)-4-[(4S)-2-tert-butyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00078
-
-
 Rattus norvegicus (2R)-4-[(4S)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine