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Literature summary for 3.4.14.5 extracted from

  • Wright, S.W.; Ammirati, M.J.; Andrews, K.M.; Brodeur, A.M.; Danley, D.E.; Doran, S.D.; Lillquist, J.S.; Liu, S.; McClure, L.D.; McPherson, R.K.; Olson, T.V.; Orena, S.J.; Parker, J.C.; Rocke, B.N.; Soeller, W.C.; Soglia, C.B.; Treadway, J.L.; Vanvolkenburg, M.A.; Zhao, Z.; Cox, E.D.
    (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization (2007), Bioorg. Med. Chem. Lett., 17, 5638-5642.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)methanol
-
 Homo sapiens
(3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-(6-pyridin-3-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(2-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(2-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(2-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(3-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(3-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(3-nitrophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(4-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(4-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-(6-methoxypyridin-3-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-[3-(trifluoromethoxy)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-1-[6-[3-(trifluoromethyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
 Homo sapiens
(3R,4S)-4-phenyl-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-amine
-
 Homo sapiens
1-(2-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
-
 Homo sapiens
1-(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
-
 Homo sapiens
1-(4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
-
 Homo sapiens
2-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
-
 Homo sapiens
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid
-
 Homo sapiens
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
-
 Homo sapiens
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenol
-
 Homo sapiens
3-[6-[(3R,4S)-3-amino-4-phenylpyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
-
 Homo sapiens
4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
-
 Homo sapiens
7-[(3R,4R)-3-amino-4-(2-methoxyphenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
-
 Homo sapiens
7-[(3R,4S)-3-amino-4-(2-methoxyphenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
-
 Homo sapiens
7-[(3R,4S)-3-amino-4-(3,4-dichlorophenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
-
 Homo sapiens
7-[(3R,4S)-3-amino-4-(4-fluorophenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
-
 Homo sapiens
7-[(3R,4S)-3-amino-4-phenylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant wild-type enzyme
-

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000005
-
-
 Homo sapiens 3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid
0.000014
-
-
 Homo sapiens (3R,4S)-1-[6-(3-nitrophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.000016
-
-
 Homo sapiens 1-(4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
0.000019
-
-
 Homo sapiens 1-(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
0.000021
-
-
 Homo sapiens (3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.000031
-
-
 Homo sapiens (3R,4S)-1-(6-pyridin-3-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.000032
-
-
 Homo sapiens (3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)methanol
0.000037
-
-
 Homo sapiens (3R,4S)-1-[6-(6-methoxypyridin-3-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.000037
-
-
 Homo sapiens 3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
0.000047
-
-
 Homo sapiens (3R,4S)-1-[6-(3-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.000051
-
-
 Homo sapiens (3R,4S)-1-[6-(3-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.000051
-
-
 Homo sapiens (3R,4S)-1-[6-(4-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.000057
-
-
 Homo sapiens (3R,4S)-1-[6-(2-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.00007
-
-
 Homo sapiens 3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenol
0.000071
-
-
 Homo sapiens (3R,4S)-1-[6-[3-(trifluoromethyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.000093
-
-
 Homo sapiens 2-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
0.00012
-
-
 Homo sapiens (3R,4S)-1-[6-(3-nitrophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.00012
-
-
 Homo sapiens (3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.00013
-
-
 Homo sapiens 4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
0.00014
-
-
 Homo sapiens 7-[(3R,4S)-3-amino-4-(4-fluorophenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
0.00015
-
-
 Homo sapiens 7-[(3R,4S)-3-amino-4-phenylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
0.00018
-
-
 Homo sapiens (3R,4S)-1-[6-(2-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.00019
-
-
 Homo sapiens (3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.0002
-
-
 Homo sapiens 7-[(3R,4S)-3-amino-4-(2-methoxyphenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
0.00023
-
-
 Homo sapiens 1-(2-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
0.000261
-
-
 Homo sapiens (3R,4S)-1-[6-(2-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.00047
-
-
 Homo sapiens (3R,4S)-1-[6-(4-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.00079
-
-
 Homo sapiens (3R,4S)-4-phenyl-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-amine
0.001
-
-
 Homo sapiens 7-[(3R,4S)-3-amino-4-(3,4-dichlorophenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
0.0013
-
-
 Homo sapiens (3R,4S)-1-[6-[3-(trifluoromethoxy)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.0014
-
-
 Homo sapiens 3-[6-[(3R,4S)-3-amino-4-phenylpyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
0.002
-
-
 Homo sapiens 7-[(3R,4R)-3-amino-4-(2-methoxyphenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
0.0023
-
-
 Homo sapiens (3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
0.0029
-
-
 Homo sapiens (3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine