Literature summary for 3.4.14.5 extracted from

Sheehan, S.M.; Mest, H.J.; Watson, B.M.; Klimkowski, V.J.; Timm, D.E.; Cauvin, A.; Parsons, S.H.; Shi, Q.; Canada, E.J.; Wiley, M.R.; Ruehter, G.; Evers, B.; Petersen, S.; Blaszczak, L.C.; Pulley, S.R.; Margolis, B.J.; Wishart, G.N.; Renson, B.; Hankotius, D.; Mohr, M.; Zechel, J.C.; Michael Kalbfleisch, J.
Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site (2007), Bioorg. Med. Chem. Lett., 17, 1765-1768.

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Homo sapiens

Inhibitors	Comment	Organism
4-[(1-[[2-oxo-2-(3-thienyl)ethyl]amino]cyclopentyl)methoxy]benzamide	-	Homo sapiens
4-[(3R)-3-[(2-oxo-2-phenylethyl)amino]butyl]benzamide	-	Homo sapiens
4-[(3R)-3-[[2-(2-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide	-	Homo sapiens
4-[(3R)-3-[[2-(3,4-difluorophenyl)-2-oxoethyl]amino]butyl]benzamide	-	Homo sapiens
4-[(3R)-3-[[2-(4-chlorophenyl)-2-oxoethyl]amino]butyl]benzamide	-	Homo sapiens
4-[(3R)-3-[[2-(4-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide	-	Homo sapiens
4-[(3R)-3-[[2-oxo-2-(3-thienyl)ethyl]amino]butyl]benzamide	-	Homo sapiens
4-[[(2R)-2-[[2-oxo-2-(3-thienyl)ethyl]amino]propyl]oxy]benzamide	-	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	P27487	recombinant enzyme	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gly-Pro-4-methylcoumarin 7-amide + H2O	-	Homo sapiens	Gly-Pro + 7-amino-4-methylcoumarin	-	?

Synonyms	Comment	Organism
dipeptidyl peptidase IV	-	Homo sapiens
DPP-IV	-	Homo sapiens

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000005	-	-	Homo sapiens	4-[(1-[[2-oxo-2-(3-thienyl)ethyl]amino]cyclopentyl)methoxy]benzamide
0.000039	-	-	Homo sapiens	4-[(3R)-3-[[2-(3,4-difluorophenyl)-2-oxoethyl]amino]butyl]benzamide
0.000084	-	-	Homo sapiens	4-[(3R)-3-[[2-(4-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide
0.00011	-	-	Homo sapiens	4-[(3R)-3-[[2-oxo-2-(3-thienyl)ethyl]amino]butyl]benzamide
0.00028	-	-	Homo sapiens	4-[(3R)-3-[(2-oxo-2-phenylethyl)amino]butyl]benzamide
0.00034	-	-	Homo sapiens	4-[[(2R)-2-[[2-oxo-2-(3-thienyl)ethyl]amino]propyl]oxy]benzamide
0.00082	-	-	Homo sapiens	4-[(3R)-3-[[2-(4-chlorophenyl)-2-oxoethyl]amino]butyl]benzamide
0.0038	-	-	Homo sapiens	4-[(3R)-3-[[2-(2-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide